naringenin

Naringenin Found in Grapefruit Prevents Obesity, Blocks Insulin Resistance in Mice

Posted May 9th, 2012 by admin
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Concentrations of the citrus-derived flavonoid in study are at higher levels than available from dietary components

July 14, 2009 - A flavonoid derived from citrus fruit has shown tremendous promise for senior citizens in new research with mice by preventing weight gain and other signs of metabolic syndrome which can lead to Type 2 Diabetes and increased risk of cardiovascular disease.

Naringenin inhibits production of hepatitis C virus

Posted August 13th, 2011 by admin
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Naringenin inhibits the assembly and long-term production of infectious hepatitis C virus particles through a PPAR-mediated mechanism.
Goldwasser J, Cohen PY, Lin W, Kitsberg D, Balaguer P, Polyak SJ, Chung RT, Yarmush ML, Nahmias Y.

Source

Center for Engineering in Medicine, Shriners Burns Hospital, Boston, MA, USA; Harvard-MIT Division of Health Science and Technology, Cambridge, MA, USA; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Abstract
BACKGROUND & AIMS:

Hepatitis C virus (HCV) infection affects 3% of the world population and is the leading cause of chronic liver disease worldwide. Current standard of care is effective in only 50% of the patients, poorly tolerated, and associated with significant side effects and viral resistance. Recently, our group and others demonstrated that the HCV lifecycle is critically dependent on host lipid metabolism and that its production is metabolically modulated.

METHODS:

The JFH1/Huh7.5.1 full lifecycle model of HCV was used to study the antiviral effects of naringenin on viral replication, assembly, and production. Activation of PPAR? was elucidated using GAL4-PPAR? fusion reporters, PPRE reporters, qRT-PCR, and metabolic studies. Metabolic results were confirmed in primary human hepatocytes

A Pilot Study of the Grapefruit Flavonoid Naringenin for the Treatment of HCV Infection

Posted June 2nd, 2011 by admin
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View of NCT01091077 on 2010_03_22

ClinicalTrials Identifier:NCT01091077
Updated:2010_03_22

Descriptive Information
Brief title

A Pilot Study of the Grapefruit Flavonoid Naringenin for HCV Infection

Archieved Video of Lloyd on the Bradley Quick Show from May 6th

Posted May 9th, 2011 by admin
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Study Finds that Natural Bioflavonoids Kill Hepatitis C Virus

Posted April 22nd, 2011 by admin
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Hepatitis C is an infectious disease of the liver that can cause miserable symptoms including fatigue, lack of appetite, abdominal pain, nausea and vomiting. Caused by a virus, hepatitis C affects about 200 million people worldwide. In the U.S. alone, one to two percent of the population is infected. Not only can this infectious disease cause scarring of the liver, cirrhosis, and eventually liver failure, but a significant number of people with hepatitis C also develop sometimes fatal liver disease or cancer.